| Our Diagnostic
Dip Chip is an integrated circuit (about 2mm X 2mm) micro-array
composed of multiple photodectectors. Each photodetector is
a small well that contains a specific antibody bound to the
surface of the photodetector. When the "DxDipChip"
is placed into water/urine, the bacteria adheres to the surface
of the chip.
For example:
Row one column A has anti-E.Coli antibody on it. Once the
E. Coli that are in the water/urine bind, another similar
antibody made to attach to E.coli and containing a luciferase(Nanolight)
antibody fusion would then bind to the E. coli previously
immobilized to the microwell detector plate.
To visualize
the E. coli, the substrate luciferin(NanoFuel) would be
added and light would be emitted right on the surface of
the chip. No need for a laser or fluorescent signal to be
analyzed.
The readout is done straight into a personal computer. The
device is small compact and could be inexpensive to build
and operate.
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