Bruce J. Bryan, MD (Updated Oct 2003 at age 49))
Prolume Ltd POB 2746 Pinetop, AZ 85935
Office-928-367-1200 Home-928-333-2001 Cell-928-242-0379 Fax-928-367-1205
Email: bbryanmd@aol.com or bruce@prolume.com

Current Objectives:
Develop applications for "Molecular Light Bulbs of the 21st Century"
Also known as Luciferases, Calcium Activated Photoproteins & Fluorescent Proteins
-BioToy.com- applying bioluminescence to children's educational & toy products.
-NanoLight.com- Cloning & Improving Fluorescent Proteins, Luciferases & substrates
-Biochip- Development of a luciferase photosensitive CCD integrated chip-ELLISA device.
-BioLight-Identification and photodynamic treatment of abnormal tissues using luciferase
-continue my practice of surgery when time allows

Reverse Chronological Activities:
Present-1996 CEO and Founder of Prolume Ltd.
Managed daily operations and developed products, and large intellectual property portfolio.

1998-1995 Private Oceanographic and Marine Research using facilities at:
Scripps Institute, University of Southern Florida, Harbor Branch Oceanographic and Southern California Marine Institute. Obtained extensive luminous marine animal collection from 1995-1998.

2003-1991 Surgical Practice (Currently not active, assist only)
Navapache Regional Medical Center, Show Low, Arizona
White Mountain Regional Medical Center, Eagar, Arizona
Good Samaritan Hospital, Phoenix, Arizona

2003-1990 Commercial real estate and land development in Arizona & New Zealand
1991-1990 Chief of Surgery: Eastern Plumas District Hospital, Portola California
1990-1987 General and Traumatic Surgical Training: San Juan Municipal Hospital, PR
197-1986 Fellowship in Pediatric Surgery: Children's Hospital of Los Angeles, CA
1986-1983 Internship and General Surgery: University of Nevada and Chicago Medical School.

Degrees:
Board Certified General Surgery (American Board of Surgery) 1995
Medical Doctor (The Chicago Medical School) 1983
Bachelor of Science in Chemistry & Biology (University of South Dakota) 1979

Education:
The Chicago Medical School: 1980-1983
Universidad Del Noreste (Mexican) Medical School1979-1980
The University of South Dakota: 1976-1979
University California Los Angeles: 1974-1976
Whittier College 1972-1974
Beverly Hills High School 1968-1972

Scientific Publications:
Shimomura O, Flood PR, Inouye S, Bryan B, Shimomura A
Isolation and properties of the luciferase stored in the ovary of the scyphozoan medusa Periphylla periphylla.
Biol Bull. 2001 Dec; 201(3):339-47.

Mahour GH, Bryan BJ, Isaacs H Jr.
Lipoblastoma and lipoblastomatosis--a report of six cases.
Surgery. 1988 Sep; 104(3):577-9.

Issued Patents:
US Pat # 6,596,257
Detection and visualization of neoplastic tissues and other tissues
-Linking antibody to luciferase, targeting tumor or abnormal tissue

US Pat # 6,458,547
Apparatus and method for detecting and identifying infectious agents
-Multiplexing array of photo detectors for simultaneous identification of multiple target compound, be they proteins, DNA, RNA, or bacteria using luciferase.
US Pat # 6,436,682
Luciferases, fluorescent proteins, nucleic acids encoding the luciferases and fluorescent proteins and the use thereof in diagnostics, high throughput screening and novelty items
-Renilla and Ptilosarcus GFPs and new luciferases applications
US Pat # 6,416,960 Detection and visualization of neoplastic tissues and other tissues
-Binding a ligand to a tumor cell and spectral shifting the emission
US Pat # 6,247,995 Bioluminescent novelty items (Bioluminescent water pump gun, a squirt gun)
US Pat # 6,232,107 Luciferases, fluorescent proteins, nucleic acids encoding the luciferases and fluorescent proteins and the use thereof in diagnostics, high throughput screening and novelty items (Discovery of several novel genes encoding fluorescent proteins and luciferases)
US Pat # 6,152,358 Bioluminescent novelty items (Glowing cosmetics and hair mousses)
US Pat # 6,113,886 Bioluminescent novelty items (Bioluminescence applied to paper products)
US Pat # 5,876,995 Bioluminescent novelty items (Bioluminescence in food & beverage products)

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